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Ano ang methotrexate?

Ang methotrexate ay gamot na nakakaapekto sa pagdami ng ilang mga cells sa katawan (anti-metabolite) at nakakababa ng aktibidad ng ating immune system (immunosuppressant). Dahil sa pagiging anti-metabolite nito, ang methotrexate - sa mataas na dose - ay ginagamit na gamot laban sa ilang uri ng kanser ng balat, baga, ulo at leeg at ng dede. Pero … Continue reading Ano ang methotrexate?

Ano ang NSAIDs?

Ang Non-Steroidal Anti-Inflammatory Drugs (or NSAIDS) ay grupo ng mga gamot na kadalasang ginagamit para maibsan ang sakit o kirot (pain reliever), mabawasan ang pamamaga (anti-inflammatory) o mapababa ang lagnat (anti-pyretic).  Ang mga ito ay ginagamit para maibsan ang mga sintomas ng sakit ng ulo, pananakit ng puson kapag may regla (dysmenorrhea), arthritis, rayuma at … Continue reading Ano ang NSAIDs?

Vitamin B for Aches and Pains

Even before you can properly assess any complaint of joint pain, paresthesias, tingling, numbness or ngalay, the typical Filipino patient already has an expectation that he'll be prescribed vitamin B. And if you do decide NOT to give it, the Pinoys will make sure to ask you about it. Some physicians give in, thinking there's … Continue reading Vitamin B for Aches and Pains

Results of a Phase IIb Study on Arhalofenate in Gout

Initiation of urate lowering therapies have been associated with an increased risk of gout flares. Hence, prophylaxis with either colchicine or naproxen has become routine in order to ameliorate this risk. Groups may vary on how long prophylaxis should be given but 6 months is generally recommended. Aside from prophylaxis, slow reduction of serum urate … Continue reading Results of a Phase IIb Study on Arhalofenate in Gout

ACR 2015 Guidelines on Rheumatoid Arthritis Part 2: Conflicts

There's this expectation that guidelines put perspective into the scheme of things as new evidence is obtained on the use of both novel and established agents. Personally, a well made algorithm is the core of guidelines as it organizes the tools available to a physician after weighing in concerns such as efficacy, safety, tolerability and, … Continue reading ACR 2015 Guidelines on Rheumatoid Arthritis Part 2: Conflicts

Pravastatin in Managing Poor Obstetric Outcomes in APAS

Anti-phospholipid antibody syndrome (APAS) is an autoimmune non-inflammatory condition characterized by vascular thrombosis and pregnancy morbidity in the background of anti-phospholipid (aPL) antibodies. Up to one-third of lupus patients may have concomitant APAS which further complicates management. Evidence suggests that presence of lupus anti-coagulants correlate with risks for developing poor pregnancy outcomes and vascular events … Continue reading Pravastatin in Managing Poor Obstetric Outcomes in APAS

ACR 2015 Guidelines for Rheumatoid Arthritis Part 1: Affirmations

Sessions on rheumatoid arthritis are guaranteed crowd-drawers in any rheumatology conference. Speakers discussing guidelines draw attention because it is a challenge keeping up with the evidence and guidelines, hopefully, put things in perspective. You can just imagine how exciting a session on RA guidelines would be. I remember attending several where the ACR 2015 guidelines … Continue reading ACR 2015 Guidelines for Rheumatoid Arthritis Part 1: Affirmations